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We are experiencing extremely slow synth fulls after upgrading to v11 as well but it is not a DDB IO bottleneck. When the synth fulls are running (several in parallel just as when on v10) the IO wait is 0, the load on the MA is 0, there is simply no blocks moving anywhere, or very little, just trickling here and there. I do have a case open for ...
Yeah, we got it to work but I guess there is a delay in support for the PowerCLI in that we cannot use tags at all anymore. Other than that (which in our case not having the tags functionality rather sucks), communication to/from vCenter works fine. We did have to repair the .Net framework though for it to work cleanly.